Dehydroepiandrosterone | You and Your Hormones from the ...
文章推薦指數: 80 %
Dehydroepiandrosterone is an important precursor hormone, and is the most abundant circulating steroid present in the human body. It has little biological ... About Contact Events News Search Search Menu Students Teachers Patients Browse About Contact Events News Topicalissues PracticalInformation YouandYourHormones Students Teachers Patients Browse Search Humanbody Home Hormones Dehydroepiandrosterone Dehydroepiandrosterone Dehydroepiandrosteroneisanimportantprecursorhormone,andisthemostabundantcirculatingsteroidpresentinthehumanbody.Ithaslittlebiologicaleffectonitsownbuthaspowerfuleffectswhenconvertedintootherhormonessuchassexsteroids. Cortisol Dihydrotestosterone Glossary AllHormones ResourcesforHormones Alternativenamesfordehydroepiandrosterone DHEA;3-beta-Hydroxy-5-androsten-17-one;syntheticversions–prastera,prasterone,fidelinandfluasterone Whatisdehydroepiandrosterone? Dehydroepiandrosteroneisaprecursorhormone,whichmeansithaslittlebiologicaleffectonitsown,buthaspowerfuleffectswhenconvertedintootherhormonessuchastestosteroneandoestradiol.Dehydroepiandrosteroneisproducedfromcholesterolmainlybytheouterlayeroftheadrenalglands,knownastheadrenalcortex,althoughitisalsomadebythetestesandovariesinsmallamounts.Itcirculatesintheblood,mainlyattachedtosulphurasdehydroepiandrosteronesulphate,whichpreventsthehormonebeingbrokendown.Inwomen, dehydroepiandrosteroneisanimportantsourceofoestrogensinthebody– itprovidesabout75%ofoestrogensbeforethe menopause,and100%ofoestrogensinthebodyaftermenopause. Dehydroepiandrosteroneproductionincreasesfromaroundnineortenyearsofage,peaksduringthe20sandgraduallydecreasesintooldage.Dehydroepiandrosteroneisalsoproducedinsmallamountsbythebrain,althoughitspreciserolethereisnotclear. Howisdehydroepiandrosteronecontrolled? Dehydroepiandrosteroneproductioniscontrolledbythebraininanegativefeedbackloop.Thismeansthatwhendehydroepiandrosteronelevelsinthebodyfall,thesystemis'switchedon'and,aslevelsrise,it'switchesoff'again. Thesystemis'switchedon'bycorticotrophin-releasinghormonebeingproducedbythehypothalamus.Thistravelstotheanteriorpituitaryglandandcausesittoreleaseadrenocorticotropichormoneintothebloodstream.Bothofthesehormonescausetheadrenalglandstoproducedehydroepiandrosterone.Whendehydroepiandrosteronelevelsrise,thebodyshutsoffproductionbystoppingcorticotrophin-releasinghormoneandadrenocorticotropichormone. WhathappensifIhavetoomuchdehydroepiandrosterone? Womenwithpolycysticovarysyndromeandhirsutismandchildrenwithcongenitaladrenalhyperplasia'data-content='1315'>congenitaladrenalhyperplasiahavehigherlevelsofdehydroepiandrosterone/dehydroepiandrosteronesulphate.Inaddition,levels maybe raisedinindividualswithcanceroftheadrenalglands(adrenalcarcinoma). Highlevelsofdehydroepiandrosteronehavealsobeenlinkedtoreducingtheriskofdepression,cardiovasculardiseaseandevendeathinsomestudies.Someexpertshavesuggesteddehydroepiandrosteronesupplementsmightovercomeage-relateddecline(aso-called'elixirofyouth')butthisisnotsupportedbycurrentevidence. Someathletesandbodybuildersalsotakedehydroepiandrosterone(ananabolicsteroid)toincreasemusclemassandstrength.Seriousside-effectsfromtakingmanufactureddehydroepiandrosteronehavebeenreportedanditisbannedbytheWorldAnti-DopingAgency.However,exerciseandcalorie-restrictionhavebeenshowntoincreasenaturaldehydroepiandrosteronelevelsinthebodyandmayleadtolongerlife. Since2000, dehydroepiandrosteronesupplementationincombinationwithgonadotropinshasbeenusedinreproductivemedicine asawaytotreatfemaleinfertility. WhathappensifIhavetoolittledehydroepiandrosterone? Lowlevelsofdehydroepiandrosteronehavebeenlinkedwithshorterlifespaninmenbutnotwomen.However,thereasonforthisisnotfullyunderstood.Decreaseddehydroepiandrosteronelevelsareassociatedwithincreasedriskofcardiovasculardiseaseinmenwithtype2diabetesmellitus'data-content='1282'>diabetesmellitusandmayalsocauseashorterlifespan,althoughfurtherresearchisneededtoconfirmthis. Inwomen,lowlevelsofdehydroepiandrosteroneareassociatedwithlowlibido,reducedbonemineraldensityandosteoporosis.However,supplementationwithcommerciallyavailable dehydroepiandrosteroneisnotrecommendedasthereisconcernaboutnumerouspossibleside-effects. Lastreviewed:Jan2017 Prev Cortisol Top Dihydrotestosterone Next RelatedGlands Pituitarygland Adrenalglands Hypothalamus Ovaries Placenta Testes ViewallGlands RelatedEndocrineConditions Hirsutism Menopause Polycysticovarysyndrome Diabetesmellitus Osteoporosis Congenitaladrenalhyperplasia Femaleinfertility ViewallEndocrineconditions RelatedHormones Adrenocorticotropichormone Oestriol Testosterone Corticotrophin-releasinghormone Oestradiol ViewallHormones RelatedGlossarySupplements depression anabolicsteroid ViewallGlossary
延伸文章資訊
- 1Dehydroepiandrosterone - Wikipedia
Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone pre...
- 2DHEA Supplements: Uses and Side Effects - WebMD
DHEA (dehydroepiandrosterone) is a hormone produced by your body's adrenal glands. These are glan...
- 3Dehydroepiandrosterone (DHEA): Uses, side effects, and ...
Fast facts on dehydroepiandrosterone (DHEA) · DHEA is an endogenous steroid hormone, produced by ...
- 4Dehydroepiandrosterone | You and Your Hormones from the ...
Dehydroepiandrosterone is an important precursor hormone, and is the most abundant circulating st...
- 5DHEA: Overview, Uses, Side Effects, Precautions, Interactions
Dehydroepiandrosterone (DHEA) is a hormone that is turned into male and female sex hormones in th...