DHEA: Overview, Uses, Side Effects, Precautions, Interactions

Dehydroepiandrosterone (DHEA) is a hormone that is turned into male and female sex hormones in the body. Prescription DHEA is used to treat thin vaginal ... MENUVITAMINS&SUPPLEMENTSCENTERFindaVitaminorSupplementFindaVitaminbyConditionAssessYourVitaminNeedsDRUGSANDMEDICATIONSCENTERFindaDrugMyMedicinePillIdentifierInteractionCheckerLatestDrugNewsFindaVitaminFindaPharmacyFIRSTAIDRESOURCESFirstAidA-ZFirstAidKit&WoundCareFirstAidMobileRELATEDTOVITAMINS&SUPPLEMENTSDrugs&MedicationsPillIdentifierMyMedicineInteractionCheckerDiet&WeightManagementFood&RecipesVitamins&SupplementsdheaDHEA-Uses,SideEffects,andMoreOTHERNAME(S):3b-Hydroxy-Androst-5-Ene-17-One,3BetaHydroxy-Andr...ShowMoreOTHERNAME(S):3b-Hydroxy-Androst-5-Ene-17-One,3BetaHydroxy-Andr...ShowMoreOverviewUsesSideEffectsPrecautionsInteractionsDosingReviews(164)OverviewDehydroepiandrosterone(DHEA)isahormonethatisturnedintomaleandfemalesexhormonesinthebody.PrescriptionDHEAisusedtotreatthinvaginaltissue.DHEAismadebytheadrenalglandsandbytheliver.DHEAlevelsseemtogodownaspeoplegetolder.DHEAlevelsseemtobelowerinpeoplewithdepressionandaftermenopause.PeoplecommonlyuseprescriptionDHEAforvaginaltissuethinning.DHEAsupplementsareusedforagingskin,depression,infertility,musclestrength,heartdisease,erectiledysfunction(ED),andmanyotherconditions,butthereisnogoodscientificevidencetosupportmanyoftheseotheruses.DHEAisbannedbytheNationalCollegiateAthleticAssociation(NCAA),theInternationalOlympicCommittee,andtheWorldAnti-DopingAgency(WADA).Don'tconfuseDHEAwith7-alpha-hydroxy-DHEA,7-beta-hydroxy-DHEA,and7-keto-DHEA.ThesearealldifferentformsofDHEAbutarenotthesameasDHEA.Uses&Effectiveness?LikelyEffectiveforThinningofvaginaltissue(vaginalatrophy).UsingvaginalinsertscontainingDHEAcanreducepainduringsexbyupto15%aftermenopause.AprescriptionDHEAproductisavailableforthiscondition.PossiblyEffectiveforAgingskin.TakingDHEAbymouthorapplyingittotheskinmightimproveskinappearanceaftermenopauseandinpeopleovertheageof60years.Depression.Taking30-500mgofDHEAbymouthdailyseemstoimprovesymptomsofdepression.Lowerdosesdon'tseemtohelp.Inabilitytobecomepregnantwithinayearoftryingtoconceive(infertility).TakingDHEAbymouthbeforein-vitrofertilization(IVF)mightimprovethechancesofpregnancyandhavingababy.Butit'snotcleariftakingDHEAhelpspreventmiscarriageafterIVF.PossiblyIneffectiveforAging.TakingDHEAbymouthdailyforupto2yearsdoesn'tseemtoimprovebodyshape,bonestrength,musclestrength,orqualityoflifeinpeopleolderthan60whohavelowDHEAlevels.Musclestrength.TakingDHEAbymouthdoesn'timprovemusclestrengthinadults.Physicalperformanceinelderlyadults.TakingDHEAbymouthdoesn'timprovephysicalperformanceinolderadults.LikelyInEffectiveforMemoryandthinkingskills(cognitivefunction).TakingDHEAbymouthdoesnotseemtoimprovementalfunctionordecreasementaldeclineinhealthyolderpeople,peoplewithHIV,orinhealthyyoungadults.Anautoimmunedisorderinwhichtheglandsthatproducetearsandsalivaaredamaged(Sjogrensyndrome).TakingDHEAbymouthdoesnotimprovesymptomsofthiscondition.ThereisinterestinusingDHEAforanumberofotherpurposes,butthereisn'tenoughreliableinformationtosaywhetheritmightbehelpful.SideEffectsWhentakenbymouth:DHEAispossiblysafewhenusedshort-term.DHEAhasbeenusedsafelyforupto2years,usuallyindosesof50mgdaily.DHEAsideeffectsareusuallymildandmightincludeacneandupsetstomach.DHEAispossiblyunsafewhenusedinhighdosesorlong-term.DonotuseDHEAindoseshigherthan50-100mgdailyorforalongperiodoftime.Usinghigherdosesorusingitlong-termcanincreasetheriskofserioussideeffectsincludingcancer.Whenappliedtotheskin:DHEAispossiblysafewhenusedappropriately.DHEAcreamhasbeenusedsafelyforupto1year.Whenappliedintothevagina:DHEAispossiblysafewhenusedappropriately.DHEAvaginalinsertshavebeensafelyusedforupto3months.SpecialPrecautionsandWarningsPregnancyandbreast-feeding:DHEAispossiblyunsafewhentakenduringpregnancyorbreast-feeding.Itcancausehigherthannormallevelsofamalehormonecalledandrogen.Thismightbeharmfultothebaby.DonotuseDHEAifyouarepregnantorbreast-feeding.Diabetes:DHEAcanaffecthowinsulinworksinthebody.Ifyouhavediabetes,monitoryourbloodsugarcarefullyifyouaretakingDHEA.Hormone-sensitiveconditionssuchasbreastcancer,uterinecancer,ovariancancer,endometriosis,oruterinefibroids:DHEAisahormonethatcanaffecthowestrogenworksinthebody.Ifyouhaveanyconditionthatmightbemadeworsebyestrogen,donotuseDHEA.Highcholesterol:DHEAmightlowerhigh-densitylipoprotein(HDLor"good")cholesterol,especiallyinfemales.Ifyouhavehighcholesterolorheartdisease,talkwithyourhealthcareproviderbeforetakingDHEA.Liverproblems:DHEAmightmakeliverproblemsworse.DonotuseDHEAifyouhaveliverproblems.Depressionandmooddisorders:DHEAmightcauseexcitability,impulsiveness,andirritabilityinpeoplewithmooddisorders.Ifyouhaveamooddisorder,talktoyourhealthcareproviderbeforetakingDHEA.Polycysticovarysyndrome(PCOS):TakingDHEAmightmakethisconditionworse.Don'tuseDHEAifyouhavePCOS.Interactions?ModerateInteractionBecautiouswiththiscombinationMedicationsforestrogensensitivecancers(Aromataseinhibitors)interactswithDHEAThebodychangesDHEAtoestrogeninthebody.Aromataseinhibitorsareusedtohelplowerestrogenlevelsinthebody.TakingDHEAmightdecreasetheeffectsofaromataseinhibitors.Fulvestrant(Faslodex)interactswithDHEAEstrogen-sensitivecancersarecancersthatareaffectedbyestrogenlevelsinthebody.Fulvestrantisusedforthesetypesofcancer.DHEAmightincreaseestrogeninthebodyanddecreasetheeffectsoffulvestrantfortreatingcancer.DonottakeDHEAifyouaretakingfulvestrant.Medicationschangedbytheliver(CytochromeP4503A4(CYP3A4)substrates)interactswithDHEASomemedicationsarechangedandbrokendownbytheliver.DHEAmightchangehowquicklytheliverbreaksdownthesemedications.Thiscouldchangetheeffectsandsideeffectsofthesemedications.Tamoxifen(Nolvadex)interactswithDHEAEstrogen-sensitivecancersarecancersthatareaffectedbyestrogenlevelsinthebody.Tamoxifenisusedtohelptreatandpreventthesetypesofcancer.DHEAincreasesestrogenlevelsinthebodyandmightdecreasetheeffectsoftamoxifen.DonottakeDHEAifyouaretakingtamoxifen.Triazolam(Halcion)interactswithDHEADHEAmightdecreasehowquicklythebodybreaksdowntriazolam.TakingDHEAwithtriazolammightincreasetheeffectsandsideeffectsoftriazolam.Medicationsthatslowbloodclotting(Anticoagulant/Antiplateletdrugs)interactswithDHEADHEAmightslowbloodclotting.TakingDHEAalongwithmedicationsthatalsoslowbloodclottingmightincreasetheriskofbruisingandbleeding.Medicationsfordepression(Antidepressantdrugs)interactswithDHEAThereissomeconcernthattakingDHEAalongwithantidepressantdrugsmightincreasetheriskforserioussideeffects.SpeakwithahealthcareproviderbeforetakingDHEAifyouaretakinganantidepressant.TuberculosisVaccineinteractswithDHEATakingDHEAmightreducetheeffectsofthetuberculosisvaccine.DonottakeDHEAifyouarereceivingatuberculosisvaccine.MinorInteractionBewatchfulwiththiscombinationEstrogensinteractswithDHEADHEAmightincreaseestrogenlevelsinthebody.TakingDHEAalongwithestrogenmightcausetoomuchestrogeninthebody.TestosteroneinteractswithDHEATakingDHEAwithtestosteronemightcausetheretobetoomuchtestosteroneinthebody.Thismightincreasetheeffectsandsideeffectsoftestosterone.DosingDHEAhasmostoftenbeenusedbyadultsatadoseof50mgbymouthdailyforupto1year.DHEAisalsoavailableintopicalcreamsandvaginalproducts.Speakwithahealthcareprovidertofindoutwhattypeofproductanddosemightbebestforaspecificcondition.NextViewReferencesREFERENCES:Sumida,Y.,Yonei,Y.,Kanemasa,K.,Hara,T.,Inada,Y.,Sakai,K.,Imai,S.,Hibino,S.,Yamaguchi,K.,Mitsuyoshi,H.,Yasui,K.,Minami,M.,Itoh,Y.,Naito,Y.,Yoshikawa,T.,andOkanoue,T.Lowercirculatinglevelsofdehydroepiandrosterone,independentofinsulinresistance,isanimportantdeterminantofseverityofnon-alcoholicsteatohepatitisinJapanesepatients.Hepatol.Res2010;40(9):901-910.Viewabstract.Sunkara,S.K.,Pundir,J.,andKhalaf,Y.Effectofandrogensupplementationormodulationonovarianstimulationoutcomeinpoorresponders:ameta-analysis.Reprod.Biomed.Online.2011;22(6):545-555.Viewabstract.Suzuki,T.,Suzuki,N.,Engleman,E.G.,Mizushima,Y.,andSakane,T.LowserumlevelsofdehydroepiandrosteronemaycausedeficientIL-2productionbylymphocytesinpatientswithsystemiclupuserythematosus(SLE).ClinExpImmunol1995;99(2):251-255.Viewabstract.Tagliaferro,A.R.,Roebuck,B.D.,Ronan,A.M.,andMeeker,L.D.Enhancementofpancreaticcarcinogenesisbydehydroepiandrosterone.Adv.Exp.MedBiol.1992;322:119-129.Viewabstract.Tagliaferro,A.R.,Ronan,A.M.,Payne,J.,Meeker,L.D.,andTse,S.Increasedlipolysistobeta-adrenergicstimulationafterdehydroepiandrosteronetreatmentinrats.AmJPhysiol1995;268(6Pt2):R1374-R1380.Viewabstract.Takayanagi,R.,Goto,K.,Suzuki,S.,Tanaka,S.,Shimoda,S.,andNawata,H.Dehydroepiandrosterone(DHEA)asapossiblesourceforestrogenformationinbonecells:correlationbetweenbonemineraldensityandserumDHEA-sulfateconcentrationinpostmenopausalwomen,andthepresenceofaromatasetobeenhancedby1,25-dihydroxyvitaminD3inhumanosteoblasts.Mech.AgeingDev.4-30-2002;123(8):1107-1114.Viewabstract.Taylor,M.K.,Padilla,G.A.,Stanfill,K.E.,Markham,A.E.,Khosravi,J.Y.,Ward,M.D.,andKoehler,M.M.Effectsofdehydroepiandrosteronesupplementationduringstressfulmilitarytraining:arandomized,controlled,double-blindfieldstudy.Stress.2012;15(1):85-96.Viewabstract.Torricelli,M.,Voltolini,C.,Galleri,L.,Biliotti,G.,Giovannelli,A.,De,BonisM.,De,PascalisF.,Centini,G.,andPetraglia,F.Amnioticfluidurocortin,CRF,oestriol,dehydroepiandrosteronesulfateandcortisolconcentrationsatmid-trimester:putativerelationshipwithpretermdelivery.EurJObstet.Gynecol.Reprod.Biol.2009;146(2):169-173.Viewabstract.Traish,A.M.,Kang,H.P.,Saad,F.,andGuay,A.T.Dehydroepiandrosterone(DHEA)--aprecursorsteroidoranactivehormoneinhumanphysiology.JSexMed2011;8(11):2960-2982.Viewabstract.Tsuji,K.,Furutama,D.,Tagami,M.,andOhsawa,N.Specificbindingandeffectsofdehydroepiandrosteronesulfate(DHEA-S)onskeletalmusclecells:possibleimplicationforDHEA-Sreplacementtherapyinpatientswithmyotonicdystrophy.LifeSci.1999;65(1):17-26.Viewabstract.Umezaki,H.,Hess,D.L.,Valenzuela,G.J.,andDucsay,C.A.Fetectomyaltersmaternalpituitary-adrenalfunctioninpregnantrhesusmacaques.BiolReprod.2001;65(5):1616-1621.Viewabstract.Uozumi,K.,Uematsu,T.,Otsuka,M.,Nakano,S.,Takatsuka,Y.,Iwahashi,M.,Hanada,S.,andArima,T.SerumdehydroepiandrosteroneandDHEA-sulfateinpatientswithadultT-cellleukemiaandhumanT-lymphotropicvirustypeIcarriers.AmJHematol.1996;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